Bacterial secreted effectors and caspase‐3 interactions
نویسندگان
چکیده
منابع مشابه
Bacterial secreted effectors and caspase-3 interactions
Apoptosis is a critical process that intrinsically links organism survival to its ability to induce controlled death. Thus, functional apoptosis allows organisms to remove perceived threats to their survival by targeting those cells that it determines pose a direct risk. Central to this process are apoptotic caspases, enzymes that form a signalling cascade, converting danger signals via initiat...
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Death by infection is often as much due to the host's reaction as it is to the direct result of microbial action. Here we identify genes in both the host and microbe that are involved in the pathogenesis of infection and disease in Drosophila melanogaster challenged with Salmonella enterica serovartyphimurium (S. typhimurium). We demonstrate that wild-typeS. typhimurium causes a lethal systemic...
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MOTIVATION Various human pathogens secret effector proteins into hosts cells via the type IV secretion system (T4SS). These proteins play important roles in the interaction between bacteria and hosts. Computational methods for T4SS effector prediction have been developed for screening experimental targets in several isolated bacterial species; however, widely applicable prediction approaches ar...
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Fungi occupy a plethora of niches and play essential roles in diverse environments through decomposition of organic material as saprophytes or through establishment of symbiotic relationships with plants and animals that range from mutually beneficial to pathogenic. During colonization of their niches, fungi secrete proteins that include carbohydrate-degrading enzymes to feed on complex molecul...
متن کاملEffective Identification of Gram-Negative Bacterial Type III Secreted Effectors Using Position-Specific Residue Conservation Profiles
BACKGROUND Type III secretion systems (T3SSs) are central to the pathogenesis and specifically deliver their secreted substrates (type III secreted proteins, T3SPs) into host cells. Since T3SPs play a crucial role in pathogen-host interactions, identifying them is crucial to our understanding of the pathogenic mechanisms of T3SSs. This study reports a novel and effective method for identifying ...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2014
ISSN: 1462-5814,1462-5822
DOI: 10.1111/cmi.12368